Kate and Julie aka Dirty Pair
It's an anime from 1985 and it has two wahmen with tits as protagonists. We got first exposed to it in 1990 when it aired on Italian TV. Funnily enough, you can watch the entire Italian dub on YouTube, as it somehow hasn't been shoah'ed by copyright.
The Italian dub censored one episode by changing the plot in such a way that a tranny was turned into a former spy. Note that this anime didn't air on Mediaset, but on some regional network. For those who aren't Italian anime experts, Mediaset has been known for censoring a lot of anime to varying degrees, while regional TV networks (that aired most anime from the late 70s until the late 90s) generally had minimal censorship, alongside MTV and TMC.